Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension
Joint Authors
Junbao, D.
Huang, Yaqian
Tang, Chaoshu
Jin, Hongfang
Liu, Jia
Chen, Selena
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sulfur dioxide (SO2), an emerging gasotransmitter, was discovered to be endogenously generated in the cardiovascular system.
Recently, the physiological effects of endogenous SO2 were confirmed.
Vascular structural remodeling (VSR), an important pathological change in many cardiovascular diseases, plays a crucial role in the pathogenesis of the diseases.
Here, the authors reviewed the research progress of endogenous SO2 in regulating VSR by searching the relevant data from PubMed and Medline.
In spontaneously hypertensive rats (SHRs) and pulmonary hypertensive rats, SO2/aspartate aminotransferase (AAT) pathway was significantly altered.
SO2 inhibited vascular smooth muscle cell (VSMC) proliferation, promoted apoptosis, inhibited the synthesis of extracellular collagen but promoted its degradation, and enhanced antioxidative capacity, thereby playing a significant role in attenuating VSR.
However, the detailed mechanisms needed to be further explored.
Further studies in this field would be important for the better understanding of the pathogenesis of systemic hypertension and pulmonary hypertension.
Also, clinical trials are needed to demonstrate if SO2 would be a potential therapeutic target in cardiovascular diseases.
American Psychological Association (APA)
Liu, Jia& Huang, Yaqian& Chen, Selena& Tang, Chaoshu& Jin, Hongfang& Junbao, D.. 2016. Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113928
Modern Language Association (MLA)
Liu, Jia…[et al.]. Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113928
American Medical Association (AMA)
Liu, Jia& Huang, Yaqian& Chen, Selena& Tang, Chaoshu& Jin, Hongfang& Junbao, D.. Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113928