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Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke
Joint Authors
Chełchowska, Magdalena
Ambroszkiewicz, Jadwiga
Gajewska, Joanna
Rowicka, Grażyna
Maciejewski, Tomasz M.
Mazur, Joanna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
Maternal smoking is considered as a source of oxidative stress, which has been implicated to disrupted adipokines expression in adipose tissue.
We examined the relationship between selected adipokines and markers of oxidative stress/antioxidant defence in the umbilical cord of neonates exposed and nonexposed in utero to tobacco smoke.
Methods.
Subjects including 85 healthy neonates (born to 41 smokers and 44 nonsmokers) were tested for adiponectin, visfatin, oxidized low density lipoprotein (ox-LDL), total oxidant capacity (TOC), and total antioxidant capacity (TAC).
Results.
Cord serum visfatin, ox-LDL, and TOC were significantly higher (p<0.001) but adiponectin and TAC were lower (p<0.001 and p<0.05, resp.) in smoking group than in tobacco abstinents.
In whole group of children (adjusted for smoking status, gender, and birth weight) adiponectin showed negative and visfatin positive correlations with ox-LDL.
In the model estimated separately for smokers ox-LDL explained 36% of adiponectin and 35.5% of visfatin variance, while in the model of nonsmokers it explained 36.8% and 69.4%, respectively.
Conclusion.
Maternal smoking enhances oxidative status and depletes antioxidant potential in newborns.
Lower level of adiponectin and higher visfatin concentration seem to be related with a less beneficial oxidative stress profile and higher level of lipid peroxidation in neonates exposed and nonexposed in utero to tobacco smoke.
American Psychological Association (APA)
Chełchowska, Magdalena& Ambroszkiewicz, Jadwiga& Gajewska, Joanna& Rowicka, Grażyna& Maciejewski, Tomasz M.& Mazur, Joanna. 2016. Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113929
Modern Language Association (MLA)
Chełchowska, Magdalena…[et al.]. Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113929
American Medical Association (AMA)
Chełchowska, Magdalena& Ambroszkiewicz, Jadwiga& Gajewska, Joanna& Rowicka, Grażyna& Maciejewski, Tomasz M.& Mazur, Joanna. Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113929