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Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
Joint Authors
Gumeni, Sentiljana
Trougakos, Ioannis P.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-09
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell.
Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival.
To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control.
An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis.
Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy.
Beyond the organelle dynamics, the constant interaction with the ubiquitin-proteasome-system (UPS) has become an emerging aspect of healthy mitochondria.
Dysfunction of mitochondria and UPS increases with age and correlates with many age-related diseases including cancer and neurodegeneration.
In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration.
American Psychological Association (APA)
Gumeni, Sentiljana& Trougakos, Ioannis P.. 2016. Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-24.
https://search.emarefa.net/detail/BIM-1113931
Modern Language Association (MLA)
Gumeni, Sentiljana& Trougakos, Ioannis P.. Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-24.
https://search.emarefa.net/detail/BIM-1113931
American Medical Association (AMA)
Gumeni, Sentiljana& Trougakos, Ioannis P.. Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-24.
https://search.emarefa.net/detail/BIM-1113931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113931