Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves’ Ophthalmopathy
Joint Authors
Wei, Yau-Huei
Tsai, Chieh-Chih
Kau, Hui-Chuan
Liu, Catherine Jui-Ling
Wu, Shi-Bei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cigarette smoking is the most important risk factor for the development or deterioration of Graves’ ophthalmopathy.
Smoke-induced increased generation of reactive oxygen species may be involved.
However, it remains to be clarified how orbital fibroblasts are affected by cigarette smoking.
Our study demonstrated that Graves’ orbital fibroblasts have exaggerated response to cigarette smoke extract challenge along with increased oxidative stress, fibrosis-related genes expression, especially connective tissue growth factor, and intracellular levels of transforming growth factor-β1 and interleukin-1β.
The findings obtained in this study provide some clues for the impact of cigarette smoking on Graves’ ophthalmopathy and offer a theoretical basis for the potential and rational use of antioxidants in treating Graves’ ophthalmopathy.
American Psychological Association (APA)
Kau, Hui-Chuan& Wu, Shi-Bei& Tsai, Chieh-Chih& Liu, Catherine Jui-Ling& Wei, Yau-Huei. 2016. Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves’ Ophthalmopathy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113937
Modern Language Association (MLA)
Kau, Hui-Chuan…[et al.]. Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves’ Ophthalmopathy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113937
American Medical Association (AMA)
Kau, Hui-Chuan& Wu, Shi-Bei& Tsai, Chieh-Chih& Liu, Catherine Jui-Ling& Wei, Yau-Huei. Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves’ Ophthalmopathy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113937