The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity
Joint Authors
Ma, Shumin
Fang, Zijun
Luo, Wenwen
Yang, Yunzhi
Wang, Chenyao
Zhang, Qian
Wang, Huafei
Chen, Huaiyong
Chan, Chi bun
Liu, Zhixue
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Excessive reactive oxygen species/reactive nitrogen species (ROS/RNS) produced as a result of ageing causes damage to macromolecules and organelles or leads to interference of cell signalling pathways, which in turn results in oxidative stress.
Oxidative stress occurs in many neurodegenerative diseases (e.g., Parkinson’s disease) and contributes to progressive neuronal loss.
In this study, we show that cell apoptosis is induced by oxidative stress and that lysosomes play an important role in cell survival under oxidative stress.
As a compensatory response to this stress, lysosomal genes were upregulated via induction of transcription factor EB (TFEB).
In addition, localization of TFEB to the nucleus was increased by oxidative stress.
We also confirmed that TFEB protects cells from oxidative stress both in vitro and in vivo.
Finally, we found that C-ETS2 senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes.
Our results demonstrate a mechanistic pathway for inducing lysosomal activity during ageing and neurodegeneration.
American Psychological Association (APA)
Ma, Shumin& Fang, Zijun& Luo, Wenwen& Yang, Yunzhi& Wang, Chenyao& Zhang, Qian…[et al.]. 2016. The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113942
Modern Language Association (MLA)
Ma, Shumin…[et al.]. The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113942
American Medical Association (AMA)
Ma, Shumin& Fang, Zijun& Luo, Wenwen& Yang, Yunzhi& Wang, Chenyao& Zhang, Qian…[et al.]. The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113942