Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hydrogen sulfide (H2S) is a well-known environmental chemical threat with an unpleasant smell of rotten eggs.
Aside from the established toxic effects of high-dose H2S, research over the past decade revealed that cells endogenously produce small amounts of H2S with physiological functions.
H2S has therefore been classified as a “gasotransmitter.” A major challenge for cells and tissues is the maintenance of low physiological concentrations of H2S in order to prevent potential toxicity.
Epithelia of the respiratory and gastrointestinal tract are especially faced with this problem, since these barriers are predominantly exposed to exogenous H2S from environmental sources or sulfur-metabolising microbiota.
In this paper, we review the cellular mechanisms by which epithelial cells maintain physiological, endogenous H2S concentrations.
Furthermore, we suggest a concept by which epithelia use their electrolyte and liquid transport machinery as defence mechanisms in order to eliminate exogenous sources for potentially harmful H2S concentrations.
American Psychological Association (APA)
Pouokam, Ervice& Althaus, Mike. 2016. Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113952
Modern Language Association (MLA)
Pouokam, Ervice& Althaus, Mike. Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113952
American Medical Association (AMA)
Pouokam, Ervice& Althaus, Mike. Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113952