Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction
Joint Authors
Buonocore, Giuseppe
Longini, M.
Lotti, Federica
Geronzi, Ursula
Guidoni, Elisa
Perrone, Serafina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Oxidative stress is a distinctive sign in several genetic disorders characterized by cancer predisposition, such as Ataxia-Telangiectasia, Fanconi Anemia, Down syndrome, progeroid syndromes, Beckwith-Wiedemann syndrome, and Costello syndrome.
Recent literature unveiled new molecular mechanisms linking oxidative stress to the pathogenesis of these conditions, with particular regard to mitochondrial dysfunction.
Since mitochondria are one of the major sites of ROS production as well as one of the major targets of their action, this dysfunction is thought to be the cause of the prooxidant status.
Deeper insight of the pathogenesis of the syndromes raises the possibility to identify new possible therapeutic targets.
In particular, the use of mitochondrial-targeted agents seems to be an appropriate clinical strategy in order to improve the quality of life and the life span of the patients.
American Psychological Association (APA)
Perrone, Serafina& Lotti, Federica& Geronzi, Ursula& Guidoni, Elisa& Longini, M.& Buonocore, Giuseppe. 2016. Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113961
Modern Language Association (MLA)
Perrone, Serafina…[et al.]. Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113961
American Medical Association (AMA)
Perrone, Serafina& Lotti, Federica& Geronzi, Ursula& Guidoni, Elisa& Longini, M.& Buonocore, Giuseppe. Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113961