Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans
Joint Authors
Li, Haifeng
Shi, Ruona
Ding, Fei
Wang, Hongyu
Han, Wenjing
Ma, Fangli
Hu, Minghua
Ma, Chung Wah
Huang, Zebo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Astragalus membranaceus is a medicinal plant traditionally used in China for a variety of conditions, including inflammatory and neural diseases.
Astragalus polysaccharides are shown to reduce the adverse effect of levodopa which is used to treat Parkinson’s disease (PD).
However, the neuroprotective effect of Astragalus polysaccharides per se in PD is lacking.
Using Caenorhabditis elegans models, we investigated the protective effect of astragalan, an acidic polysaccharide isolated from A.
membranaceus, against the neurotoxicity of 6-hydroxydopamine (6-OHDA), a neurotoxin that can induce parkinsonism.
We show that 6-OHDA is able to degenerate dopaminergic neurons and lead to the deficiency of food-sensing behavior and a shorter lifespan in C.
elegans.
Interestingly, these degenerative symptoms can be attenuated by astragalan treatment.
Astragalan is also shown to alleviate oxidative stress through reducing reactive oxygen species level and malondialdehyde content and increasing superoxide dismutase and glutathione peroxidase activities and reduce the expression of proapoptotic gene egl-1 in 6-OHDA-intoxicated nematodes.
Further studies reveal that astragalan is capable of elevating the decreased acetylcholinesterase activity induced by 6-OHDA.
Together, our results demonstrate that the protective effect of astragalan against 6-OHDA neurotoxicity is likely due to the alleviation of oxidative stress and regulation of apoptosis pathway and cholinergic system and thus provide an important insight into the therapeutic potential of Astragalus polysaccharide in neurodegeneration.
American Psychological Association (APA)
Li, Haifeng& Shi, Ruona& Ding, Fei& Wang, Hongyu& Han, Wenjing& Ma, Fangli…[et al.]. 2016. Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113968
Modern Language Association (MLA)
Li, Haifeng…[et al.]. Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113968
American Medical Association (AMA)
Li, Haifeng& Shi, Ruona& Ding, Fei& Wang, Hongyu& Han, Wenjing& Ma, Fangli…[et al.]. Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113968