NADPH Oxidase: A Potential Target for Treatment of Stroke
Joint Authors
Duan, Xiaochun
Shen, Haitao
Zhang, Li
Wu, Jie
Tian, Xiaodi
Sun, Qing
Hang, Chunhua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Stroke is the third leading cause of death in industrialized nations.
Oxidative stress is involved in the pathogenesis of stroke, and excessive generation of reactive oxygen species (ROS) by mitochondria is thought to be the main cause of oxidative stress.
NADPH oxidase (NOX) enzymes have recently been identified and studied as important producers of ROS in brain tissues after stroke.
Several reports have shown that knockout or deletion of NOX exerts a neuroprotective effect in three major experimental stroke models.
Recent studies also confirmed that NOX inhibitors ameliorate brain injury and improve neurological outcome after stroke.
However, the physiological and pathophysiological roles of NOX enzymes in the central nervous system (CNS) are not known well.
In this review, we provide a comprehensive summary of our current understanding about expression and physiological function of NOX enzymes in the CNS and its pathophysiological roles in the three major types of stroke: ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage.
American Psychological Association (APA)
Zhang, Li & Wu, Jie & Duan, Xiaochun& Tian, Xiaodi & Shen, Haitao& Sun, Qing…[et al.]. 2016. NADPH Oxidase: A Potential Target for Treatment of Stroke. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113979
Modern Language Association (MLA)
Zhang, Li…[et al.]. NADPH Oxidase: A Potential Target for Treatment of Stroke. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113979
American Medical Association (AMA)
Zhang, Li & Wu, Jie & Duan, Xiaochun& Tian, Xiaodi & Shen, Haitao& Sun, Qing…[et al.]. NADPH Oxidase: A Potential Target for Treatment of Stroke. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113979