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Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity
Joint Authors
Battistelli, Michela
Vallorani, Luciana
Falcieri, Elisabetta
Fimognari, Carmela
Stocchi, Vilberto
Luchetti, Francesca
Canonico, Barbara
Calcabrini, Cinzia
Diaz, Anna Rita
Papa, Stefano
Romanello, Vanina
Sandri, Marco
Ciacci, Caterina
Barbieri, Elena
Sestili, Piero
Guescini, Michele
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Creatine (Cr) is a nutritional supplement promoting a number of health benefits.
Indeed Cr has been shown to be beneficial in disease-induced muscle atrophy, improve rehabilitation, and afford mild antioxidant activity.
The beneficial effects are likely to derive from pleiotropic interactions.
In accord with this notion, we previously demonstrated that multiple pleiotropic effects, including preservation of mitochondrial damage, account for the capacity of Cr to prevent the differentiation arrest caused by oxidative stress in C2C12 myoblasts.
Given the importance of mitochondria in supporting the myogenic process, here we further explored the protective effects of Cr on the structure, function, and networking of these organelles in C2C12 cells differentiating under oxidative stressing conditions; the effects on the energy sensor AMPK, on PGC-1α, which is involved in mitochondrial biogenesis and its downstream effector Tfam were also investigated.
Our results indicate that damage to mitochondria is crucial in the differentiation imbalance caused by oxidative stress and that the Cr-prevention of these injuries is invariably associated with the recovery of the normal myogenic capacity.
We also found that Cr activates AMPK and induces an upregulation of PGC-1α expression, two events which are likely to contribute to the protection of mitochondrial quality and function.
American Psychological Association (APA)
Barbieri, Elena& Guescini, Michele& Calcabrini, Cinzia& Vallorani, Luciana& Diaz, Anna Rita& Fimognari, Carmela…[et al.]. 2016. Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113989
Modern Language Association (MLA)
Barbieri, Elena…[et al.]. Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113989
American Medical Association (AMA)
Barbieri, Elena& Guescini, Michele& Calcabrini, Cinzia& Vallorani, Luciana& Diaz, Anna Rita& Fimognari, Carmela…[et al.]. Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113989