Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide
Joint Authors
Ma, Qingyong
Zhang, Lun
Zong, Liang
Jiang, Zhengdong
Chen, Xin
Li, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetes mellitus (DM) and pancreatic cancer are intimately related, as approximately 85% of patients diagnosed with pancreatic cancer have impaired glucose tolerance or even DM.
Our previous studies have indicated that high glucose could promote the invasive and migratory abilities of pancreatic cancer cells.
We therefore explored the underlying mechanism that hyperglycemia modulates the metastatic potential of pancreatic cancer.
Our data showed that streptozotocin- (STZ-) treated diabetic nude mice exhibit larger tumor size than that of the euglycemic mice.
The number of nude mice that develop liver metastasis or ascites is much more in the STZ-treated group than that in the euglycemic group.
Hyperglycemic mice contain a higher plasma H2O2-level than that from euglycemic mice.
The injection of polyethylene glycol-conjugated catalase (PEG-CAT), an H2O2 scavenger, may reverse hyperglycemia-induced tumor metastasis.
In addition, hyperglycemia could also modulate the expression of epithelial-mesenchymal transition- (EMT-) related factors in pancreatic tumor tissues, as the E-cadherin level is decreased and the expression of mesenchymal markers N-cadherin and vimentin as well as transcription factor snail is strongly increased.
The injection of PEG-CAT could also reverse hyperglycemia-induced EMT.
These results suggest that the association between hyperglycemia and poor prognosis of pancreatic cancer can be attributed to the alterations of EMT through the production of hydrogen peroxide.
American Psychological Association (APA)
Li, Wei& Zhang, Lun& Chen, Xin& Jiang, Zhengdong& Zong, Liang& Ma, Qingyong. 2016. Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113990
Modern Language Association (MLA)
Li, Wei…[et al.]. Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113990
American Medical Association (AMA)
Li, Wei& Zhang, Lun& Chen, Xin& Jiang, Zhengdong& Zong, Liang& Ma, Qingyong. Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113990