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Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation
Joint Authors
Kost, Olga A.
Beznos, Olga V.
Davydova, Nina G.
Manickam, Devika S.
Nikolskaya, Irina I.
Guller, Anna E.
Binevski, Petr V.
Chesnokova, Natalia B.
Shekhter, Anatoly B.
Klyachko, Natalia L.
Kabanov, Alexander V.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential.
This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed “nanozyme.” The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, poly(L-lysine)-poly(ethyleneglycol), followed by covalent cross-linking of the complexes with 3,3′-dithiobis(sulfosuccinimidylpropionate) sodium salt.
The ability of SOD1 nanozyme as well as the native SOD1 to reduce inflammatory processes in the eye was examined in vivo in rabbits with immunogenic uveitis.
Results suggested that topical instillations of both enzyme forms demonstrated anti-inflammatory activity; however, the nanozyme was much more effective compared to the free enzyme in decreasing uveitis manifestations.
In particular, we noted statistically significant differences in such inflammatory signs in the eye as the intensities of corneal and iris edema, hyperemia of conjunctiva, lens opacity, fibrin clots, and the protein content in aqueous humor.
Clinical findings were confirmed by histological data.
Thus, SOD1-containing nanozyme is potentially useful therapeutic agent for the treatment of ocular inflammatory disorders.
American Psychological Association (APA)
Kost, Olga A.& Beznos, Olga V.& Davydova, Nina G.& Manickam, Devika S.& Nikolskaya, Irina I.& Guller, Anna E.…[et al.]. 2015. Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113991
Modern Language Association (MLA)
Kost, Olga A.…[et al.]. Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113991
American Medical Association (AMA)
Kost, Olga A.& Beznos, Olga V.& Davydova, Nina G.& Manickam, Devika S.& Nikolskaya, Irina I.& Guller, Anna E.…[et al.]. Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113991