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Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator
Joint Authors
Estabrooks, Paul A.
Cheng, Zhiyong
Zheng, Louise D.
Linarelli, Leah E.
Brooke, Joseph
Smith, Cayleen
Wall, Sarah S.
Greenawald, Mark H.
Seidel, Richard W.
Almeida, Fabio A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type 2 diabetes (T2D) is characterized by mitochondrial derangement and oxidative stress.
With no known cure for T2D, it is critical to identify mitochondrial biomarkers for early diagnosis of prediabetes and disease prevention.
Here we examined 87 participants on the diagnosis power of fasting glucose (FG) and hemoglobin A1c levels and investigated their interactions with mitochondrial DNA methylation.
FG and A1c led to discordant diagnostic results irrespective of increased body mass index (BMI), underscoring the need of new biomarkers for prediabetes diagnosis.
Mitochondrial DNA methylation levels were not correlated with late-stage (impaired FG or A1c) but significantly with early-stage (impaired insulin sensitivity) events.
Quartiles of BMI suggested that mitochondrial DNA methylation increased drastically from Q1 (20 < BMI < 24.9, lean) to Q2 (30 < BMI < 34.9, obese), but marginally from Q2 to Q3 (35 < BMI < 39.9, severely obese) and from Q3 to Q4 (BMI > 40, morbidly obese).
A significant change was also observed from Q1 to Q2 in HOMA insulin sensitivity but not in A1c or FG.
Thus, mitochondrial epigenetic changes link to increased diabetes risk and the indicator of early-stage prediabetes.
Further larger-scale studies to examine the potential of mitochondrial epigenetic marker in prediabetes diagnosis will be of critical importance for T2D prevention.
American Psychological Association (APA)
Zheng, Louise D.& Linarelli, Leah E.& Brooke, Joseph& Smith, Cayleen& Wall, Sarah S.& Greenawald, Mark H.…[et al.]. 2016. Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114006
Modern Language Association (MLA)
Zheng, Louise D.…[et al.]. Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114006
American Medical Association (AMA)
Zheng, Louise D.& Linarelli, Leah E.& Brooke, Joseph& Smith, Cayleen& Wall, Sarah S.& Greenawald, Mark H.…[et al.]. Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114006