Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
Joint Authors
Pardo, Fabián
Leiva, Andrea
Fuenzalida, Bárbara
Toledo, Fernando
Gutiérrez, Jaime
Sanhueza, Carlos
Salomon, Carlos
Sobrevia, Luis
Westermeier, Francisco
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Maternal physiological hypercholesterolemia occurs during pregnancy, ensuring normal fetal development.
In some cases, the maternal plasma cholesterol level increases to above this physiological range, leading to maternal supraphysiological hypercholesterolemia (MSPH).
This condition results in endothelial dysfunction and atherosclerosis in the fetal and placental vasculature.
The fetal and placental endothelial dysfunction is related to alterations in the L-arginine/nitric oxide (NO) pathway and the arginase/urea pathway and results in reduced NO production.
The level of tetrahydrobiopterin (BH4), a cofactor for endothelial NO synthase (eNOS), is reduced in nonpregnant women who have hypercholesterolemia, which favors the generation of the superoxide anion rather than NO (from eNOS), causing endothelial dysfunction.
However, it is unknown whether MSPH is associated with changes in the level or metabolism of BH4; as a result, eNOS function is not well understood.
This review summarizes the available information on the potential link between MSPH and BH4 in causing human fetoplacental vascular endothelial dysfunction, which may be crucial for understanding the deleterious effects of MSPH on fetal growth and development.
American Psychological Association (APA)
Leiva, Andrea& Fuenzalida, Bárbara& Westermeier, Francisco& Toledo, Fernando& Salomon, Carlos& Gutiérrez, Jaime…[et al.]. 2015. Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114012
Modern Language Association (MLA)
Leiva, Andrea…[et al.]. Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114012
American Medical Association (AMA)
Leiva, Andrea& Fuenzalida, Bárbara& Westermeier, Francisco& Toledo, Fernando& Salomon, Carlos& Gutiérrez, Jaime…[et al.]. Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114012