The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases
Joint Authors
Pei, Haifeng
Yang, Yi
Zhao, Heng
Li, Xiuchuan
Yang, Dachun
Li, De
Yang, Yongjian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ischemic heart diseases (IHD) have become the leading cause of death around the world, killing more than 7 million people annually.
In IHD, the blockage of coronary vessels will cause irreversible cell injury and even death.
As the “powerhouse” and “apoptosis center” in cardiomyocytes, mitochondria play critical roles in IHD.
Ischemia insult can reduce myocardial ATP content, resulting in energy stress and overproduction of reactive oxygen species (ROS).
Thus, mitochondrial abnormality has been identified as a hallmark of multiple cardiovascular disorders.
To date, many studies have suggested that these mitochondrial proteins, such as electron transport chain (ETC) complexes, uncoupling proteins (UCPs), mitochondrial dynamic proteins, translocases of outer membrane (Tom) complex, and mitochondrial permeability transition pore (MPTP), can directly or indirectly influence mitochondria-originated ROS production, consequently determining the degree of mitochondrial dysfunction and myocardial impairment.
Here, the focus of this review is to summarize the present understanding of the relationship between some mitochondrial functional proteins and ROS production in IHD.
American Psychological Association (APA)
Pei, Haifeng& Yang, Yi& Zhao, Heng& Li, Xiuchuan& Yang, Dachun& Li, De…[et al.]. 2016. The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114024
Modern Language Association (MLA)
Pei, Haifeng…[et al.]. The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114024
American Medical Association (AMA)
Pei, Haifeng& Yang, Yi& Zhao, Heng& Li, Xiuchuan& Yang, Dachun& Li, De…[et al.]. The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114024