Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse
Joint Authors
Steinert, Joern
Bradley, Sophie A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nitric oxide (NO) is an important gasotransmitter molecule that is involved in numerous physiological processes throughout the nervous system.
In addition to its involvement in physiological plasticity processes (long-term potentiation, LTP; long-term depression, LTD) which can include NMDAR-mediated calcium-dependent activation of neuronal nitric oxide synthase (nNOS), new insights into physiological and pathological consequences of nitrergic signalling have recently emerged.
In addition to the canonical cGMP-mediated signalling, NO is also implicated in numerous pathways involving posttranslational modifications.
In this review we discuss the multiple effects of S-nitrosylation and 3-nitrotyrosination on proteins with potential modulation of function but limit the analyses to signalling involved in synaptic transmission and vesicular release.
Here, crucial proteins which mediate synaptic transmission can undergo posttranslational modifications with either pre- or postsynaptic origin.
During normal brain function, both pathways serve as important cellular signalling cascades that modulate a diverse array of physiological processes, including synaptic plasticity, transcriptional activity, and neuronal survival.
In contrast, evidence suggests that aging and disease can induce nitrosative stress via excessive NO production.
Consequently, uncontrolled S-nitrosylation/3-nitrotyrosination can occur and represent pathological features that contribute to the onset and progression of various neurodegenerative diseases, including Parkinson’s, Alzheimer’s, and Huntington’s.
American Psychological Association (APA)
Bradley, Sophie A.& Steinert, Joern. 2015. Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114034
Modern Language Association (MLA)
Bradley, Sophie A.& Steinert, Joern. Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114034
American Medical Association (AMA)
Bradley, Sophie A.& Steinert, Joern. Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114034