Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo

Abstract EN

We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical ( • O H ) in a dose-dependent manner.

Since most of the ionizing radiation- (IR-) induced injuries were caused by • O H , this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo.

We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks (DSBs) and apoptosis of human lymphocyte AHH-1 cells.

This study also showed that GSPs could protect white blood cells (WBC) from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde (MDA), thus improving the survival rates of mice after ionizing radiation.

It is suggested that GSPs have a potential as an effective and safe radioprotective agent.