Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells
Joint Authors
Skała, Ewa
Wysokińska, Halina
Sitarek, Przemysław
Szemraj, Janusz
Śliwiński, Tomasz
Różalski, Marek
Krajewska, Urszula
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rhaponticum carthamoides has a long tradition of use in Siberian folk medicine.
The roots and rhizomes of this species are used in various dietary supplements or nutraceutical preparations to increase energy level or eliminate physical weakness.
This is the first report to reveal the protective and DNA repair stimulating abilities of R.
carthamoides root extracts in Chinese hamster ovary (CHO) cells exposed to an oxidative agent.
Both transformed root extract (TR extract) and extract of soil-grown plant roots (NR extract) may be responsible for stimulating CHO cells to repair oxidatively induced DNA damage, but CHO cells stimulated with extract from the transformed roots demonstrated significantly stronger properties than cells treated with the soil-grown plant root extract.
These differences in biological activity may be attributed to the differences in the content of phenolic compounds in these root extracts.
Preincubation of the CHO cells with TR and NR extracts showed an increase in gene expression and protein levels of catalase (CAT) and superoxide dismutase (SOD2).
R.
carthamoides may possess antioxidant properties that protect CHO cells against oxidative stress.
American Psychological Association (APA)
Skała, Ewa& Sitarek, Przemysław& Różalski, Marek& Krajewska, Urszula& Szemraj, Janusz& Wysokińska, Halina…[et al.]. 2016. Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114046
Modern Language Association (MLA)
Skała, Ewa…[et al.]. Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114046
American Medical Association (AMA)
Skała, Ewa& Sitarek, Przemysław& Różalski, Marek& Krajewska, Urszula& Szemraj, Janusz& Wysokińska, Halina…[et al.]. Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114046