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Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model
Joint Authors
Rahim, Ahad A.
Hristova, Mariya
Rocha-Ferreira, Eridan
Rudge, Brogan
Hughes, Michael P.
Robertson, Nicola J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention that could be administered as an alternative to cooling in cases of perinatal hypoxia-ischemia (HI).
In the current study we hypothesized that RIPostC in the piglet model of birth asphyxia confers protection by reducing nitrosative stress and subsequent nitrotyrosine formation, as well as having an effect on glial immunoreactivity.
Postnatal day 1 (P1) piglets underwent HI brain injury and were randomised to HI (control) or HI + RIPostC.
Immunohistochemistry assessment 48 hours after HI revealed a significant decrease in brain nitrotyrosine deposits in the RIPostC-treated group ( p = 0.02 ).
This was accompanied by a significant increase in eNOS expression ( p < 0.0001 ) and decrease in iNOS ( p = 0.010 ), with no alteration in nNOS activity.
Interestingly, RIPostC treatment was associated with a significant increase in GFAP ( p = 0.002 ) and IBA1 ( p = 0.006 ), markers of astroglial and microglial activity, respectively.
The current study demonstrates a beneficial effect of RIPostC therapy in the preclinical piglet model of neonatal asphyxia, which appears to be mediated by modulation of nitrosative stress, despite glial activation.
American Psychological Association (APA)
Rocha-Ferreira, Eridan& Rudge, Brogan& Hughes, Michael P.& Rahim, Ahad A.& Hristova, Mariya& Robertson, Nicola J.. 2016. Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114048
Modern Language Association (MLA)
Rocha-Ferreira, Eridan…[et al.]. Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114048
American Medical Association (AMA)
Rocha-Ferreira, Eridan& Rudge, Brogan& Hughes, Michael P.& Rahim, Ahad A.& Hristova, Mariya& Robertson, Nicola J.. Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114048