Positive Modulation of Pink Nelumbo nucifera Flowers on Memory Impairment, Brain Damage, and Biochemical Profiles in Restraint Rats
Joint Authors
Wattanathorn, Jintanaporn
Prabsattroo, Thawatchai
Somsapt, Pichet
Sritragool, Opass
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Due to the crucial role of oxidative stress in the stress-induced memory deficit, the benefit of substance possessing antioxidant effect is focused.
Since no data are available, we aimed to determine the effect of Nelumbo nucifera flowers extract on spatial memory and hippocampal damage in stressed rats.
Male Wistar rats, weighing 250–350 g, were orally given N.
nucifera extract at doses of 10, 10, and 200 mg·kg−1 45 minutes before the exposure to 12-hour restraint stress.
The spatial memory and serum corticosterone were assessed at 7 and 14 days of study period.
At the end of study, acetylcholinesterase (AChE), monoamine oxidase type A and monoamine oxidase type B (MAO-A and MAO-B), oxidative stress status, neuron density, and Ki67 expression in hippocampus were also assessed.
The results showed that N.
nucifera extract decreased memory deficit and brain damage, serum corticosterone, oxidative stress status, AChE, and MAO-A and MAO-B activities but increased neuron density and Ki67 expression in hippocampus.
These suggested that the improved oxidative stress status, adult neurogenesis, and cholinergic and monoaminergic functions might be responsible for the protective effect against stress-related brain damage and dysfunction of the extract.
Therefore, N.
nucifera extract is the potential neuroprotective and memory enhancing agent.
However, further researches are still required.
American Psychological Association (APA)
Prabsattroo, Thawatchai& Wattanathorn, Jintanaporn& Somsapt, Pichet& Sritragool, Opass. 2015. Positive Modulation of Pink Nelumbo nucifera Flowers on Memory Impairment, Brain Damage, and Biochemical Profiles in Restraint Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114049
Modern Language Association (MLA)
Prabsattroo, Thawatchai…[et al.]. Positive Modulation of Pink Nelumbo nucifera Flowers on Memory Impairment, Brain Damage, and Biochemical Profiles in Restraint Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114049
American Medical Association (AMA)
Prabsattroo, Thawatchai& Wattanathorn, Jintanaporn& Somsapt, Pichet& Sritragool, Opass. Positive Modulation of Pink Nelumbo nucifera Flowers on Memory Impairment, Brain Damage, and Biochemical Profiles in Restraint Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114049