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Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats
Joint Authors
Barceló, Pere
Nicolau, Cristina
Gamundí, Antoni
Fiol, Maria A.
Tresguerres, Jesús A. F.
Akaârir, Mourad
Rial, Rubén V.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Growth hormone (GH) and melatonin are two hormones with quite different physiological effects.
Curiously, their secretion shows parallel and severe age-related reductions.
This has promoted many reports for studying the therapeutic supplementation of both hormones in an attempt to avoid or delay the physical, physiological, and psychological decay observed in aged humans and in experimental animals.
Interestingly, the effects of the external administration of low doses of GH and of melatonin were surprisingly similar, as both hormones caused significant improvements in the functional capabilities of aged subjects.
The present report aims at discerning the eventual difference between cognitive and motor effects of the two hormones when administered to young and aged Wistar rats.
The effects were tested in the radial maze, a test highly sensitive to the age-related impairments in working memory and also in the rotarod test, for evaluating the motor coordination.
The results showed that both hormones caused clear improvements in both tasks.
However, while GH improved the cognitive capacity and, most importantly, the physical stamina, the effects of melatonin should be attributed to its antioxidant, anxiolytic, and neuroprotective properties.
American Psychological Association (APA)
Barceló, Pere& Nicolau, Cristina& Gamundí, Antoni& Fiol, Maria A.& Tresguerres, Jesús A. F.& Akaârir, Mourad…[et al.]. 2016. Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114062
Modern Language Association (MLA)
Barceló, Pere…[et al.]. Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1114062
American Medical Association (AMA)
Barceló, Pere& Nicolau, Cristina& Gamundí, Antoni& Fiol, Maria A.& Tresguerres, Jesús A. F.& Akaârir, Mourad…[et al.]. Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114062