Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2HO-1 Signaling Pathway
Joint Authors
Cho, Hyuk Jin
Ha, U-Syn
Lee, Ji Youl
Hwang, Sung Yeoun
Kim, Kang Sup
Kim, Su Jin
Kim, Sae Woong
Hong, Sung Hoo
Bae, Woong Jin
Choi, Jin Bong
Wang, Zhiping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Higher testicular temperature results in altered spermatogenesis due to heat-related oxidative stress.
We examined the effects of decursin extracted from Angelica gigas Nakai on antioxidant activity in vitro and in a cryptorchidism-induced infertility rat model.
TM3 Leydig cell viability was measured based on oxidative stress according to treatment.
Either distilled water or AG 400 mg/kg of A.
gigas extract was administered orally for 4 weeks after unilateral cryptorchidism was induced.
After 1, 2, and 4 weeks, six rats from the control group and six rats from treatment group were sacrificed.
Testicular weight, semen quality, antioxidant activities, nuclear factor erythroid 2-related factor 2 (Nrf2) protein, and mRNA expression of Nrf2-regulated genes were analyzed.
Treatment with A.
gigas extract (1) protected TM3 cells against oxidative stress in a dose-dependent manner, (2) improved the mean weight of the cryptorchid testis, (3) maintained sperm counts, motility, and spermatogenic cell density, (4) decreased levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased levels of superoxide dismutase (SOD), (5) significantly increased Nrf2 and heme oxygenase-1 (HO-1), and (6) significantly decreased apoptosis.
This study suggests that decursin extracted from A.
gigas is a supplemental agent that can reduce oxidative stress by Nrf2-mediated upregulation of HO-1 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism-induced infertility.
American Psychological Association (APA)
Bae, Woong Jin& Ha, U-Syn& Choi, Jin Bong& Kim, Kang Sup& Kim, Su Jin& Cho, Hyuk Jin…[et al.]. 2016. Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2HO-1 Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114066
Modern Language Association (MLA)
Bae, Woong Jin…[et al.]. Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2HO-1 Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114066
American Medical Association (AMA)
Bae, Woong Jin& Ha, U-Syn& Choi, Jin Bong& Kim, Kang Sup& Kim, Su Jin& Cho, Hyuk Jin…[et al.]. Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2HO-1 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114066