Neoatherosclerosis after Drug-Eluting Stent Implantation: Roles and Mechanisms
Joint Authors
Shi, Da-Zhuo
Liu, Yue
Chen, Keji
Cui, Yuanyuan
Zhao, Fuhai
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In-stent neoatherosclerosis (NA), characterized by a relatively thin fibrous cap and large volume of yellow-lipid accumulation after drug-eluting stents (DES) implantation, has attracted much attention owing to its close relationship with late complications, such as revascularization and late stent thrombosis (ST).
Accumulating evidence has demonstrated that more than one-third of patients with first-generation DES present with NA.
Even in the advent of second-generation DES, NA still occurs.
It is indicated that endothelial dysfunction induced by DES plays a critical role in neoatherosclerotic development.
Upregulation of reactive oxygen species (ROS) induced by DES implantation significantly affects endothelial cells healing and functioning, therefore rendering NA formation.
In light of the role of ROS in suppression of endothelial healing, combining antioxidant therapies with stenting technology may facilitate reestablishing a functioning endothelium to improve clinical outcome for patients with stenting.
American Psychological Association (APA)
Cui, Yuanyuan& Liu, Yue& Zhao, Fuhai& Shi, Da-Zhuo& Chen, Keji. 2016. Neoatherosclerosis after Drug-Eluting Stent Implantation: Roles and Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114069
Modern Language Association (MLA)
Cui, Yuanyuan…[et al.]. Neoatherosclerosis after Drug-Eluting Stent Implantation: Roles and Mechanisms. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114069
American Medical Association (AMA)
Cui, Yuanyuan& Liu, Yue& Zhao, Fuhai& Shi, Da-Zhuo& Chen, Keji. Neoatherosclerosis after Drug-Eluting Stent Implantation: Roles and Mechanisms. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114069