Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis
Joint Authors
Bimonte, Sabrina
Barbieri, Antonio
Ciliberto, Gennaro
Montella, Maurizio
Crispo, Anna
Capunzo, Mario
Nocerino, Flavia
D’Ursi, Anna Maria
Tecce, Mario Felice
Galdiero, Massimiliano
Giudice, Aldo
Rotondo, Emanuela
Scrima, Mario
Franci, Gianluigi
D'Arena, Giovanni
Montella, Maurizio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
MicroRNAs are short (21–23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs.
Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms.
Additionally, recent studies reported that miRNAs can also be encoded by certain single-cell eukaryotes and by viruses.
The vast majority of viral miRNAs are encoded by the herpesviruses family.
These DNA viruses including Epstein-Barr virus encode their own miRNAs and/or manipulate the expression of cellular miRNAs to facilitate respective infection cycles.
Modulation of the control pathways of miRNAs expression is often involved in the promotion of tumorigenesis through a specific cascade of transduction signals.
Notably, latent infection with Epstein-Barr virus is considered liable of causing several types of malignancies, including the majority of gastric carcinoma cases detected worldwide.
In this review, we describe the role of the Epstein-Barr virus in gastric carcinogenesis, summarizing the functions of the Epstein-Barr virus-encoded viral proteins and related epigenetic alterations as well as the roles of Epstein-Barr virus-encoded and virally modulated cellular miRNAs.
American Psychological Association (APA)
Giudice, Aldo& D'Arena, Giovanni& Crispo, Anna& Tecce, Mario Felice& Nocerino, Flavia& Montella, Maurizio…[et al.]. 2016. Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114075
Modern Language Association (MLA)
Giudice, Aldo…[et al.]. Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114075
American Medical Association (AMA)
Giudice, Aldo& D'Arena, Giovanni& Crispo, Anna& Tecce, Mario Felice& Nocerino, Flavia& Montella, Maurizio…[et al.]. Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114075