New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
Joint Authors
Sánchez-Lozada, Laura Gabriela
Scholze, Alexandra
Tapia, Edilia
Pedraza-Chaverri, José
Osorio, Horacio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-27
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals.
In combination with a reduced antioxidant capacity this causes oxidative stress.
This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications.
We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction.
Recent antioxidant therapy options including the use of vitamin D and pharmacologic therapies for hyperuricemia are discussed.
Finally, we review some new therapy options in diabetic nephropathy including antidiabetic agents (noninsulin dependent), plant antioxidants, and food components as alternative antioxidant therapies.
American Psychological Association (APA)
Pedraza-Chaverri, José& Sánchez-Lozada, Laura Gabriela& Osorio, Horacio& Tapia, Edilia& Scholze, Alexandra. 2016. New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1114080
Modern Language Association (MLA)
Pedraza-Chaverri, José…[et al.]. New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-21.
https://search.emarefa.net/detail/BIM-1114080
American Medical Association (AMA)
Pedraza-Chaverri, José& Sánchez-Lozada, Laura Gabriela& Osorio, Horacio& Tapia, Edilia& Scholze, Alexandra. New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1114080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114080