Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus
Joint Authors
Brambila, Eduardo
Treviño, Samuel
Velázquez-Vázquez, Denisse
Sánchez-Lara, Eduardo
Diaz-Fonseca, Alfonso
Flores-Hernandez, José Ángel
Pérez-Benítez, Aarón
González-Vergara, Enrique
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
New potential drugs based on vanadium are being developed as possible treatments for diabetes mellitus (DM) and its complications.
In this regard, our working group developed metforminium decavanadate (MetfDeca), a compound with hypoglycemic and hypolipidemic properties.
MetfDeca was evaluated in models of type 1 and type 2 diabetes mellitus, on male Wistar rats.
Alloxan-induction was employed to produce DM1 model, while a hypercaloric-diet was employed to generate DM2 model.
Two-month treatments with 3.7 μg (2.5 μM)/300 g/twice a week for DM2 and 7.18 μg (4.8 μM)/300 g/twice a week for DM1 of MetfDeca, respectively, were administered.
The resulting pharmacological data showed nontoxicological effects on liver and kidney.
At the same time, MetfDeca showed an improvement of carbohydrates and lipids in tissues and serum.
MetfDeca treatment was better than the monotherapies with metformin for DM2 and insulin for DM1.
Additionally, MetfDeca showed a protective effect on pancreatic beta cells of DM1 rats, suggesting a possible regeneration of these cells, since they recovered their insulin levels.
Therefore, MetfDeca could be considered not only as an insulin-mimetic agent, but also as an insulin-enhancing agent.
Efforts to elucidate the mechanism of action of this compound are now in progress.
American Psychological Association (APA)
Treviño, Samuel& Velázquez-Vázquez, Denisse& Sánchez-Lara, Eduardo& Diaz-Fonseca, Alfonso& Flores-Hernandez, José Ángel& Pérez-Benítez, Aarón…[et al.]. 2016. Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114082
Modern Language Association (MLA)
Treviño, Samuel…[et al.]. Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114082
American Medical Association (AMA)
Treviño, Samuel& Velázquez-Vázquez, Denisse& Sánchez-Lara, Eduardo& Diaz-Fonseca, Alfonso& Flores-Hernandez, José Ángel& Pérez-Benítez, Aarón…[et al.]. Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114082