![](/images/graphics-bg.png)
Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy
Joint Authors
Pronzato, Maria Adelaide
Colla, Renata
Ciucis, Chiara De
Furfaro, Anna Lisa
Nitti, Mariapaola
Marinari, Umberto Maria
Traverso, Nicola
Domenicotti, Cinzia
Marengo, Barbara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Reactive oxygen species (ROS) and their products are components of cell signaling pathways and play important roles in cellular physiology and pathophysiology.
Under physiological conditions, cells control ROS levels by the use of scavenging systems such as superoxide dismutases, peroxiredoxins, and glutathione that balance ROS generation and elimination.
Under oxidative stress conditions, excessive ROS can damage cellular proteins, lipids, and DNA, leading to cell damage that may contribute to carcinogenesis.
Several studies have shown that cancer cells display an adaptive response to oxidative stress by increasing expression of antioxidant enzymes and molecules.
As a double-edged sword, ROS influence signaling pathways determining beneficial or detrimental outcomes in cancer therapy.
In this review, we address the role of redox homeostasis in cancer growth and therapy and examine the current literature regarding the redox regulatory systems that become upregulated in cancer and their role in promoting tumor progression and resistance to chemotherapy.
American Psychological Association (APA)
Marengo, Barbara& Nitti, Mariapaola& Furfaro, Anna Lisa& Colla, Renata& Ciucis, Chiara De& Marinari, Umberto Maria…[et al.]. 2016. Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1114093
Modern Language Association (MLA)
Marengo, Barbara…[et al.]. Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1114093
American Medical Association (AMA)
Marengo, Barbara& Nitti, Mariapaola& Furfaro, Anna Lisa& Colla, Renata& Ciucis, Chiara De& Marinari, Umberto Maria…[et al.]. Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1114093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114093