Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

Joint Authors

Kim, Jeong-Mi
Noh, Eun-Mi
Park, Jinny
Song, Hwa-Ryung
Lee, Minok
Song, Hyun-Kyung
Hong, On-Yu
Whang, Pyoung H.
Han, Myung-Kwan
Kwon, Kang-Beom
Kim, Jong-Suk
Lee, Young-Rae

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-11-27

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging.

ROS induce skin aging through their damaging effect on cellular constituents.

However, the origins of ROS have not been fully elucidated.

We investigated that ROS generation of replicative senescent fibroblasts is generated by the modulation of phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism.

Reduction of the PTEN protein, which dephosphorylates PIP3, was responsible for maintaining a high level of PIP3 in replicative cells and consequently mediated the activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway.

Increased ROS production was blocked by inhibition of PI3K or protein kinase C (PKC) or by NADPH oxidase activating in replicative senescent cells.

These data indicate that the signal pathway to ROS generation in replicative aged skin cells can be stimulated by reduced PTEN level.

Our results provide new insights into skin aging-associated modification of the PI3K/NADPH oxidase signaling pathway and its relationship with a skin aging-dependent increase of ROS in human dermal fibroblasts.

American Psychological Association (APA)

Noh, Eun-Mi& Park, Jinny& Song, Hwa-Ryung& Kim, Jeong-Mi& Lee, Minok& Song, Hyun-Kyung…[et al.]. 2016. Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114108

Modern Language Association (MLA)

Noh, Eun-Mi…[et al.]. Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114108

American Medical Association (AMA)

Noh, Eun-Mi& Park, Jinny& Song, Hwa-Ryung& Kim, Jeong-Mi& Lee, Minok& Song, Hyun-Kyung…[et al.]. Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114108

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1114108