Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts
Joint Authors
Kim, Jeong-Mi
Noh, Eun-Mi
Park, Jinny
Song, Hwa-Ryung
Lee, Minok
Song, Hyun-Kyung
Hong, On-Yu
Whang, Pyoung H.
Han, Myung-Kwan
Kwon, Kang-Beom
Kim, Jong-Suk
Lee, Young-Rae
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging.
ROS induce skin aging through their damaging effect on cellular constituents.
However, the origins of ROS have not been fully elucidated.
We investigated that ROS generation of replicative senescent fibroblasts is generated by the modulation of phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism.
Reduction of the PTEN protein, which dephosphorylates PIP3, was responsible for maintaining a high level of PIP3 in replicative cells and consequently mediated the activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway.
Increased ROS production was blocked by inhibition of PI3K or protein kinase C (PKC) or by NADPH oxidase activating in replicative senescent cells.
These data indicate that the signal pathway to ROS generation in replicative aged skin cells can be stimulated by reduced PTEN level.
Our results provide new insights into skin aging-associated modification of the PI3K/NADPH oxidase signaling pathway and its relationship with a skin aging-dependent increase of ROS in human dermal fibroblasts.
American Psychological Association (APA)
Noh, Eun-Mi& Park, Jinny& Song, Hwa-Ryung& Kim, Jeong-Mi& Lee, Minok& Song, Hyun-Kyung…[et al.]. 2016. Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114108
Modern Language Association (MLA)
Noh, Eun-Mi…[et al.]. Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114108
American Medical Association (AMA)
Noh, Eun-Mi& Park, Jinny& Song, Hwa-Ryung& Kim, Jeong-Mi& Lee, Minok& Song, Hyun-Kyung…[et al.]. Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114108