Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes
Joint Authors
Tan, Wen
Fan, Zhuo
Wen, Ting
Chen, Yaoxu
Huang, Lijie
Lin, Wei
Yin, Chunxia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
K A T P channel is an important mediator or factor in physiological and pathological metabolic pathway.
Activation of K A T P channel has been identified to be a critical step in the cardioprotective mechanism against IR injury.
On the other hand, desensitization of the channel to its opener or the metabolic ligand ATP in pathological conditions, like cardiac hypertrophy, would decrease the adaption of myocardium to metabolic stress and is a disadvantage for drug therapy.
Isosteviol, obtained by acid hydrolysis of stevioside, has been demonstrated to play a cardioprotective role against diseases of cardiovascular system, like anti-IR injury, antihypertension, antihyperglycemia, and so forth.
The present study investigated the effect of isosteviol (STV) on sarc K A T P channel current induced by pinacidil and mitochondrial flavoprotein oxidation induced by diazoxide.
Our results showed that preincubating cells with STV not only increased the current amplitude and activating rate of sarc K A T P channels induced by pinacidil but also potentiated diazoxide-elicited oxidation of flavoprotein in mitochondria.
American Psychological Association (APA)
Fan, Zhuo& Wen, Ting& Chen, Yaoxu& Huang, Lijie& Lin, Wei& Yin, Chunxia…[et al.]. 2016. Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114110
Modern Language Association (MLA)
Fan, Zhuo…[et al.]. Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114110
American Medical Association (AMA)
Fan, Zhuo& Wen, Ting& Chen, Yaoxu& Huang, Lijie& Lin, Wei& Yin, Chunxia…[et al.]. Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114110