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Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies
Joint Authors
Mileo, Anna Maria
Miccadei, Stefania
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Cancer onset and progression have been linked to oxidative stress by increasing DNA mutations or inducing DNA damage, genome instability, and cell proliferation and therefore antioxidant agents could interfere with carcinogenesis.
It is well known that conventional radio-/chemotherapies influence tumour outcome through ROS modulation.
Since these antitumour treatments have important side effects, the challenge is to develop new anticancer therapeutic strategies more effective and less toxic for patients.
To this purpose, many natural polyphenols have emerged as very promising anticancer bioactive compounds.
Beside their well-known antioxidant activities, several polyphenols target epigenetic processes involved in cancer development through the modulation of oxidative stress.
An alternative strategy to the cytotoxic treatment is an approach leading to cytostasis through the induction of therapy-induced senescence.
Many anticancer polyphenols cause cellular growth arrest through the induction of a ROS-dependent premature senescence and are considered promising antitumour therapeutic tools.
Furthermore, one of the most innovative and interesting topics is the evaluation of efficacy of prooxidant therapies on cancer stem cells (CSCs).
Several ROS inducers-polyphenols can impact CSCs metabolisms and self-renewal related pathways.
Natural polyphenol roles, mainly in chemoprevention and cancer therapies, are described and discussed in the light of the current literature data.
American Psychological Association (APA)
Mileo, Anna Maria& Miccadei, Stefania. 2015. Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114119
Modern Language Association (MLA)
Mileo, Anna Maria& Miccadei, Stefania. Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1114119
American Medical Association (AMA)
Mileo, Anna Maria& Miccadei, Stefania. Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114119