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Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response
Joint Authors
Freires, Irlan de Almeida
Rosalen, Pedro Luiz
Jofré, Ignacio
Pezoa, Cesar
Cuevas, Magdalena
Scheuermann, Erick
Romero, Fernando
de Alencar, Severino Matias
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases.
In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz.
(Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response.
Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses.
The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified.
Murtilla extract did not generate toxic effects on human endothelial cells and had significant antioxidant activity against ROS production, lipid peroxidation, and superoxide anion production.
Furthermore, it showed dose-dependent vasodilator activity in aortic rings in the presence of endothelium, whose hypotensive mechanism is partially mediated by nitric oxide synthase/guanylate cyclase and large-conductance calcium-dependent potassium channels.
Murtilla fruits might potentially have beneficial effects on the management of cardiovascular diseases.
American Psychological Association (APA)
Jofré, Ignacio& Pezoa, Cesar& Cuevas, Magdalena& Scheuermann, Erick& Freires, Irlan de Almeida& Rosalen, Pedro Luiz…[et al.]. 2016. Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114122
Modern Language Association (MLA)
Jofré, Ignacio…[et al.]. Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114122
American Medical Association (AMA)
Jofré, Ignacio& Pezoa, Cesar& Cuevas, Magdalena& Scheuermann, Erick& Freires, Irlan de Almeida& Rosalen, Pedro Luiz…[et al.]. Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114122