Resveratrol Regulates Mitochondrial Biogenesis and FissionFusion to Attenuate Rotenone-Induced Neurotoxicity
Joint Authors
Cao, Jia
Peng, Kaige
Tao, Yuan
Zhang, Jun
Wang, Jian
Ye, Feng
Dan, Guorong
Zhao, Yuanpeng
Cai, Ying
Zhao, Jiqing
Wu, Qiang
Sai, Yan
Zou, Zhongmin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
It has been confirmed that mitochondrial impairment may underlie both sporadic and familial Parkinson’s disease (PD).
Mitochondrial fission/fusion and biogenesis are key processes in regulating mitochondrial homeostasis.
Therefore, we explored whether the protective effect of resveratrol in rotenone-induced neurotoxicity was associated with mitochondrial fission/fusion and biogenesis.
The results showed that resveratrol could not only promote mitochondrial mass and DNA copy number but also improve mitochondrial homeostasis and neuron function in rats and PC12 cells damaged by rotenone.
We also observed effects with alterations in proteins known to regulate mitochondrial fission/fusion and biogenesis in rotenone-induced neurotoxicity.
Therefore, our findings suggest that resveratrol may prevent rotenone-induced neurotoxicity through regulating mitochondrial fission/fusion and biogenesis.
American Psychological Association (APA)
Peng, Kaige& Tao, Yuan& Zhang, Jun& Wang, Jian& Ye, Feng& Dan, Guorong…[et al.]. 2015. Resveratrol Regulates Mitochondrial Biogenesis and FissionFusion to Attenuate Rotenone-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114126
Modern Language Association (MLA)
Peng, Kaige…[et al.]. Resveratrol Regulates Mitochondrial Biogenesis and FissionFusion to Attenuate Rotenone-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114126
American Medical Association (AMA)
Peng, Kaige& Tao, Yuan& Zhang, Jun& Wang, Jian& Ye, Feng& Dan, Guorong…[et al.]. Resveratrol Regulates Mitochondrial Biogenesis and FissionFusion to Attenuate Rotenone-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114126