SIRT1: A Novel Target for the Treatment of Muscular Dystrophies
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration.
Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy and is caused by mutations in the gene that encodes the cytoskeletal protein dystrophin.
The treatment for DMD is limited to glucocorticoids, which are associated with multiple side effects.
Thus, the identification of novel therapeutic targets is urgently needed.
SIRT1 is an NAD+-dependent histone/protein deacetylase that plays roles in diverse cellular processes, including stress resistance and cell survival.
Studies have shown that SIRT1 activation provides beneficial effects in the dystrophin-deficient mdx mouse, a model of DMD.
SIRT1 activation leads to the attenuation of oxidative stress and inflammation, a shift from the fast to slow myofiber phenotype, and the suppression of tissue fibrosis.
Although further research is needed to clarify the molecular mechanisms underlying the protective role of SIRT1 in mdx mice, we propose SIRT1 as a novel therapeutic target for patients with muscular dystrophies.
American Psychological Association (APA)
Kuno, Atsushi& Horio, Yoshiyuki. 2016. SIRT1: A Novel Target for the Treatment of Muscular Dystrophies. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114128
Modern Language Association (MLA)
Kuno, Atsushi& Horio, Yoshiyuki. SIRT1: A Novel Target for the Treatment of Muscular Dystrophies. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114128
American Medical Association (AMA)
Kuno, Atsushi& Horio, Yoshiyuki. SIRT1: A Novel Target for the Treatment of Muscular Dystrophies. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114128