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Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation
Joint Authors
Matias, Andreza Cândido
Cerchiaro, Giselle
Manieri, Tânia Maria
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We report the molecular mechanism for zinc depletion caused by TPEN (N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine) in neuroblastoma cells.
The activation of p38 MAP kinase and subsequently caspase 3 is not due to or followed by redox imbalance or ROS generation, though these are commonly observed in literature.
We found that TPEN is not responsible for ROS generation and the mechanism involves essentially lysosomal disruption caused by intracellular zinc depletion.
We also observed a modest activation of Bax and no changes in the Bcl-2 proteins.
As a result, we suggest that TPEN causes intracellular zinc depletion which can influence the breakdown of lysosomes and cell death without ROS generation.
American Psychological Association (APA)
Matias, Andreza Cândido& Manieri, Tânia Maria& Cerchiaro, Giselle. 2016. Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114130
Modern Language Association (MLA)
Matias, Andreza Cândido…[et al.]. Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114130
American Medical Association (AMA)
Matias, Andreza Cândido& Manieri, Tânia Maria& Cerchiaro, Giselle. Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114130