Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROSERKMMP Pathway in Pancreatic Cancer
Joint Authors
Li, Xuqi
Duan, Wanxing
Lei, Jianjun
Ma, Qingyong
Zhang, Lun
Zong, Liang
Li, Wei
Shan, Tao
Li, Jiahui
Chen, Ke
Xu, Qinhong
Sun, Hao
Chen, Xin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lipoxin A4 (LXA4), an endogenous arachidonic acid metabolite, was previously considered an anti-inflammatory lipid mediator.
But it also has the potential to inhibit cancer progression.
To explore the therapeutic effect of LXA4 in pancreatic cancer, we used Panc-1 cells to investigate the mechanism by which LXA4 can attenuate pancreatic cancer cell invasion.
Our data showed that LXA4 significantly inhibited both cell invasion and the expression of matrix metalloproteinase- (MMP-) 9 and MMP-2.
Further experiments implied that LXA4 decreased the levels of intracellular reactive oxygen species (ROS) and the activity of the extracellular signal regulated kinases (ERK) pathway to achieve similar outcome to ROS scavenger N-acetyl-l-cysteine (NAC).
However, a decreased level of intracellular ROS was not observed in cells treated with the specific ERK pathway inhibitor FR180204.
The blocking of either intracellular ROS or ERK pathway caused the downregulation of MMP-9 and MMP-2 expression.
Furthermore, tests revealed that LXA4 inhibited MMP-9 and MMP-2 at the mRNA, protein, and functional levels.
Finally, LXA4 dramatically limited the invasion of CoCl2-mimic hypoxic cells and abrogated intracellular ROS levels, ERK activity, and MMPs expression.
These results suggest that LXA4 attenuates cell invasion in pancreatic cancer by suppressing the ROS/ERK/MMPs pathway, which may be beneficial for preventing the invasion of pancreatic cancer.
American Psychological Association (APA)
Zong, Liang& Li, Jiahui& Chen, Xin& Chen, Ke& Li, Wei& Li, Xuqi…[et al.]. 2015. Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROSERKMMP Pathway in Pancreatic Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114134
Modern Language Association (MLA)
Zong, Liang…[et al.]. Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROSERKMMP Pathway in Pancreatic Cancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114134
American Medical Association (AMA)
Zong, Liang& Li, Jiahui& Chen, Xin& Chen, Ke& Li, Wei& Li, Xuqi…[et al.]. Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROSERKMMP Pathway in Pancreatic Cancer. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114134