Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant
Joint Authors
Chen, Yeng
Uthaya Kumar, U. Seeta
Sasidharan, Sreenivasan
Kanwar, Jagat R.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The therapeutic potential of Cassia surattensis in reducing free radical-induced oxidative stress and inflammation particularly in hepatic diseases was evaluated in this study.
The polyphenol rich C.
surattensis seed extract showed good in vitro antioxidant.
C.
surattensis seed extract contained total phenolic content of 100.99 mg GAE/g dry weight and there was a positive correlation (r>0.9) between total phenolic content and the antioxidant activities of the seed extract.
C.
surattensis seed extract significantly (p<0.05) reduced the elevated levels of serum liver enzymes (ALT, AST, and ALP) and relative liver weight in paracetamol-induced liver hepatotoxicity in mice.
Moreover, the extract significantly (p<0.05) enhanced the antioxidant enzymes and glutathione (GSH) contents in the liver tissues, which led to decrease of malondialdehyde (MDA) level.
The histopathological examination showed the liver protective effect of C.
surattensis seed extract against paracetamol-induced histoarchitectural alterations by maximum recovery in the histoarchitecture of the liver tissue.
Furthermore, histopathological observations correspondingly supported the biochemical assay outcome, that is, the significant reduction in elevated levels of serum liver enzymes.
In conclusion, C.
surattensis seed extract enhanced the in vivo antioxidant status and showed antihepatotoxic activities, which is probably due to the presence of phenolic compounds.
American Psychological Association (APA)
Uthaya Kumar, U. Seeta& Chen, Yeng& Kanwar, Jagat R.& Sasidharan, Sreenivasan. 2016. Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114137
Modern Language Association (MLA)
Uthaya Kumar, U. Seeta…[et al.]. Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114137
American Medical Association (AMA)
Uthaya Kumar, U. Seeta& Chen, Yeng& Kanwar, Jagat R.& Sasidharan, Sreenivasan. Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114137