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Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies
Joint Authors
Choi, Min Hee
Ow, Jin Rong
Yang, Nai-Di
Taneja, Reshma
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Oxidative stress is a loss of balance between the production of reactive oxygen species during cellular metabolism and the mechanisms that clear these species to maintain cellular redox homeostasis.
Increased oxidative stress has been associated with muscular dystrophy, and many studies have proposed mechanisms that bridge these two pathological conditions at the molecular level.
In this review, the evidence indicating a causal role of oxidative stress in the pathogenesis of various muscular dystrophies is revisited.
In particular, the mediation of cellular redox status in dystrophic muscle by NF-κB pathway, autophagy, telomere shortening, and epigenetic regulation are discussed.
Lastly, the current stance of targeting these pathways using antioxidant therapies in preclinical and clinical trials is examined.
American Psychological Association (APA)
Choi, Min Hee& Ow, Jin Rong& Yang, Nai-Di& Taneja, Reshma. 2015. Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114138
Modern Language Association (MLA)
Choi, Min Hee…[et al.]. Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114138
American Medical Association (AMA)
Choi, Min Hee& Ow, Jin Rong& Yang, Nai-Di& Taneja, Reshma. Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114138