Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases
Joint Authors
Zhang, Zhongwei
Xu, Xiao-Chao
Liu, Ting
Yuan, Shu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Reactive oxygen species (ROS) play a crucial role in the inflammatory response and cytokine outbreak, such as during virus infections, diabetes, cancer, cardiovascular diseases, and neurodegenerative diseases.
Therefore, antioxidant is an important medicine to ROS-related diseases.
For example, ascorbic acid (vitamin C, VC) was suggested as the candidate antioxidant to treat multiple diseases.
However, long-term use of high-dose VC causes many side effects.
In this review, we compare and analyze all kinds of mitochondrion-permeable antioxidants, including edaravone, idebenone, α-Lipoic acid, carotenoids, vitamin E, and coenzyme Q10, and mitochondria-targeted antioxidants MitoQ and SkQ and propose astaxanthin (a special carotenoid) to be the best antioxidant for ROS-burst-mediated acute diseases, like avian influenza infection and ischemia-reperfusion.
Nevertheless, astaxanthins are so unstable that most of them are inactivated after oral administration.
Therefore, astaxanthin injection is suggested hypothetically.
The drawbacks of the antioxidants are also reviewed, which limit the use of antioxidants as coadjuvants in the treatment of ROS-associated disorders.
American Psychological Association (APA)
Zhang, Zhongwei& Xu, Xiao-Chao& Liu, Ting& Yuan, Shu. 2015. Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114141
Modern Language Association (MLA)
Zhang, Zhongwei…[et al.]. Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114141
American Medical Association (AMA)
Zhang, Zhongwei& Xu, Xiao-Chao& Liu, Ting& Yuan, Shu. Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114141