Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet
Joint Authors
Li, Peng
Zhang, Junping
Li, Ming
Yang, Cui
Zhou, Yanan
Zhang, Guangyin
Xu, Yingzhi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify HO-1 and other related antioxidant enzymes as molecular target for active redox compounds.
Second, our experiments have pointed out an association between statin treatment and a decrease in the risk of having peroxidation damage of brain.
The balance effects of simvastatin to ROS and antioxidants enzymes network are most probably due to improved SOD functional activity, increase in GSH-Px, increase in HO-1 expression, and decrease of MDA generation.
American Psychological Association (APA)
Zhang, Guangyin& Li, Ming& Xu, Yingzhi& Li, Peng& Yang, Cui& Zhou, Yanan…[et al.]. 2015. Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114145
Modern Language Association (MLA)
Zhang, Guangyin…[et al.]. Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114145
American Medical Association (AMA)
Zhang, Guangyin& Li, Ming& Xu, Yingzhi& Li, Peng& Yang, Cui& Zhou, Yanan…[et al.]. Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114145