Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid
Joint Authors
Park, Seon Kyeong
Guo, Tianjiao
Heo, Ho Jin
Ha, Jeong Su
Kim, Dae-Ok
Kang, Jin Yong
Lee, Du Sang
Kim, Jong Min
Lee, Uk
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The antiamnesic effect of 3,5-dicaffeoylquinic acid (3,5-diCQA) as the main phenolic compound in Artemisia argyi H.
extract on cognitive dysfunction induced by trimethyltin (TMT) (7.1 μg/kg of body weight; intraperitoneal injection) was investigated in order to assess its ameliorating function in mice.
In several behavioral tests, namely, the Y-maze, passive avoidance, and Morris water maze (MWM) test, 3,5-diCQA significantly ameliorated learning and memory deficits.
After the behavioral tests, brain tissues from the mice were analyzed to characterize the basis of the neuroprotective effect.
Acetylcholine (ACh) levels increased, whereas the activity of acetylcholinesterase (AChE) decreased upon administration of 3,5-diCQA.
In addition, 3,5-diCQA effectively protected against an increase in malondialdehyde (MDA) content, an increase in the oxidized glutathione (GSH) ratio, and a decline of total superoxide dismutase (SOD) level.
3,5-diCQA may prevent neuronal apoptosis through the protection of mitochondrial activities and the repression of apoptotic signaling molecules such as p-Akt, BAX, and p-tau (Ser 404).
American Psychological Association (APA)
Kang, Jin Yong& Park, Seon Kyeong& Guo, Tianjiao& Ha, Jeong Su& Lee, Du Sang& Kim, Jong Min…[et al.]. 2016. Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114161
Modern Language Association (MLA)
Kang, Jin Yong…[et al.]. Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114161
American Medical Association (AMA)
Kang, Jin Yong& Park, Seon Kyeong& Guo, Tianjiao& Ha, Jeong Su& Lee, Du Sang& Kim, Jong Min…[et al.]. Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114161