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Punicalagin Induces Serum Low-Density Lipoprotein Influx to Macrophages
Joint Authors
Sela, Shifra
Atrahimovich, Dana
Samson, Abraham O.
Khatib, Soliman
Vaya, Jacob
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High levels of circulating low-density lipoprotein (LDL) are a primary initiating event in the development of atherosclerosis.
Recently, the antiatherogenic effect of polyphenols has been shown to be exerted via a mechanism unrelated to their antioxidant capacity and to stem from their interaction with specific intracellular or plasma proteins.
In this study, we investigated the interaction of the main polyphenol in pomegranate, punicalagin, with apolipoprotein B-100 (ApoB100) that surrounds LDL.
Punicalagin bound to ApoB100 at low concentrations (0.25–4 μM).
Upon binding, it induced LDL influx to macrophages in a concentration-dependent manner, up to 2.5-fold.
In contrast, another polyphenol which binds to ApoB100, glabridin, did not affect LDL influx.
We further showed that LDL influx occurs specifically through the LDL receptor, with LDL then accumulating in the cell cytoplasm.
Taken together with the findings of Aviram et al., 2000, that pomegranate juice and punicalagin induce plasma LDL removal and inhibit macrophage cholesterol synthesis and accumulation, our results suggest that, upon binding, punicalagin stimulates LDL influx to macrophages, thus reducing circulating cholesterol levels.
American Psychological Association (APA)
Atrahimovich, Dana& Khatib, Soliman& Sela, Shifra& Vaya, Jacob& Samson, Abraham O.. 2016. Punicalagin Induces Serum Low-Density Lipoprotein Influx to Macrophages. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114176
Modern Language Association (MLA)
Atrahimovich, Dana…[et al.]. Punicalagin Induces Serum Low-Density Lipoprotein Influx to Macrophages. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114176
American Medical Association (AMA)
Atrahimovich, Dana& Khatib, Soliman& Sela, Shifra& Vaya, Jacob& Samson, Abraham O.. Punicalagin Induces Serum Low-Density Lipoprotein Influx to Macrophages. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114176