Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats
Joint Authors
Ebaid, Hossam
Alhazza, Ibrahim
Bashandy, Samir A. E.
El Awdan, Sally A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study aimed to examine the protective role of Spirulina platensis (S.
platensis) against arsenic-induced testicular oxidative damage in rats.
Arsenic (in the form of NaAsO2 at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicular superoxide dismutase (SOD), catalase (CAT), reduced glutathione, and zinc.
Moreover, it significantly decreased plasma testosterone, luteinizing hormone (LH), triiodothyronine (T3), and thyroxine (T4) levels and reduced sperm motility and sperm count.
Arsenic (AS) led to a significant increase in testicular malondialdehyde (MDA), tumour necrosis factor alpha (TNF-α), nitric oxide (NO), and sperm abnormalities.
S.
platensis at a dose of 300 mg/kg was found to attenuate As-induced oxidative stress, testicular damage, and sperm abnormalities by its potent antioxidant activity.
S.
platensis may represent a potential therapeutic option to protect the testicular tissue from arsenic intoxication.
American Psychological Association (APA)
Bashandy, Samir A. E.& El Awdan, Sally A.& Ebaid, Hossam& Alhazza, Ibrahim. 2016. Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114177
Modern Language Association (MLA)
Bashandy, Samir A. E.…[et al.]. Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114177
American Medical Association (AMA)
Bashandy, Samir A. E.& El Awdan, Sally A.& Ebaid, Hossam& Alhazza, Ibrahim. Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114177