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SIRT13 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model
Joint Authors
Zeng, Zhenhua
Chen, Zhongqing
Zhao, Ke-seng
Zhang, Qin
Gao, Youguang
Xu, Siqi
Wei, Siwei
Dai, Xingui
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sepsis often results in damage to multiple organ systems, possibly due to severe mitochondrial dysfunction.
Two members of the sirtuin family, SIRT1 and SIRT3, have been implicated in the reversal of mitochondrial damage.
The aim of this study was to determine the role of SIRT1/3 in acute kidney injury (AKI) following sepsis in a septic rat model.
After drug pretreatment and cecal ligation and puncture (CLP) model reproduction in the rats, we performed survival time evaluation and kidney tissue extraction and renal tubular epithelial cell (RTEC) isolation.
We observed reduced SIRT1/3 activity, elevated acetylated SOD2 (ac-SOD2) levels and oxidative stress, and damaged mitochondria in RTECs following sepsis.
Treatment with resveratrol (RSV), a chemical SIRT1 activator, effectively restored SIRT1/3 activity, reduced acetylated SOD2 levels, ameliorated oxidative stress and mitochondrial function of RTECs, and prolonged survival time.
However, the beneficial effects of RSV were greatly abrogated by Ex527, a selective inhibitor of SIRT1.
These results suggest a therapeutic role for SIRT1 in the reversal of AKI in septic rat, which may rely on SIRT3-mediated deacetylation of SOD2.
SIRT1/3 activation could therefore be a promising therapeutic strategy to treat sepsis-associated AKI.
American Psychological Association (APA)
Xu, Siqi& Gao, Youguang& Zhang, Qin& Wei, Siwei& Chen, Zhongqing& Dai, Xingui…[et al.]. 2016. SIRT13 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114182
Modern Language Association (MLA)
Xu, Siqi…[et al.]. SIRT13 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114182
American Medical Association (AMA)
Xu, Siqi& Gao, Youguang& Zhang, Qin& Wei, Siwei& Chen, Zhongqing& Dai, Xingui…[et al.]. SIRT13 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114182