Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad
Joint Authors
Muscarella, Lucia Anna
Sparaneo, Angelo
Fabrizio, Federico Pio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-25
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The transcription factor Nrf2 (NF-E2 related factor 2) is a master regulator of the cell antioxidant response associated with tumor growth and resistance to cytotoxic treatments.
In particular, Nrf2 induces upregulation of cytoprotective genes by interacting with the closely situated AREs (Antioxidant Response Elements) in response to endogenous or exogenous stress stimuli and takes part to several oncogenic signaling pathways.
Among these, the crosstalk with Notch pathway has been shown to enhance cytoprotection and maintenance of cellular homeostasis, tissue organization by modulating cell proliferation kinetics, and stem cell self-renewal in several organs.
The role of Notch and Nrf2 related pathways in tumorigenesis is highly variable and when they are both abnormally activated they can synergistically cause neoplastic proliferation by promoting cell survival, differentiation, invasion, and metastases.
NFE2L2, KEAP1, and NOTCH genes family appear in the list of significantly mutated genes in tumors in both combined and individual sets, supporting the crucial role that the aberrant Nrf2-Notch crosstalk might have in cancerogenesis.
In this review, we summarize current knowledge about the alterations of Nrf2 and Notch pathways and their reciprocal transcriptional regulation throughout tumorigenesis and progression of lung tumors, supporting the potentiality of putative biomarkers and therapeutic targets.
American Psychological Association (APA)
Sparaneo, Angelo& Fabrizio, Federico Pio& Muscarella, Lucia Anna. 2016. Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114183
Modern Language Association (MLA)
Sparaneo, Angelo…[et al.]. Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1114183
American Medical Association (AMA)
Sparaneo, Angelo& Fabrizio, Federico Pio& Muscarella, Lucia Anna. Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114183