Exercise Training Improves the Altered Renin-Angiotensin System in the Rostral Ventrolateral Medulla of Hypertensive Rats
Joint Authors
Wu, Zhao-Tang
Ren, Chang-zhen
Yang, Ya-Hong
Sun, Jia-cen
Zhang, Ru-Wen
Shen, Du
Wang, Yang-Kai
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The imbalance between angiotensin II (Ang II) and angiotensin 1–7 (Ang 1–7) in the brain has been reported to contribute to cardiovascular dysfunction in hypertension.
Exercise training (ExT) is beneficial to hypertension and the mechanism is unclear.
This study was aimed to determine if ExT improves hypertension via adjusting renin angiotensin system in cardiovascular centers including the rostral ventrolateral medulla (RVLM).
Spontaneously hypertensive rats (SHR, 8 weeks old) were subjected to low-intensity ExT or kept sedentary (Sed) for 12 weeks.
Blood pressure elevation coupled with increase in age was significantly decreased in SHR received ExT compared with Sed.
The results in vivo showed that ExT significantly reduced or increased the cardiovascular responses to central application of sarthran (antagonist of Ang II) or A779 (antagonist of Ang 1–7), respectively.
The protein expression of the Ang II acting receptor AT1R and the Ang 1–7 acting receptor Mas in the RVLM was significantly reduced and elevated in SHR following ExT, respectively.
Moreover, production of reactive oxygen species in the RVLM was significantly decreased in SHR following ExT.
The current data suggest that ExT improves hypertension via improving the balance of Ang II and Ang 1–7 and antioxidative stress at the level of RVLM.
American Psychological Association (APA)
Ren, Chang-zhen& Yang, Ya-Hong& Sun, Jia-cen& Wu, Zhao-Tang& Zhang, Ru-Wen& Shen, Du…[et al.]. 2016. Exercise Training Improves the Altered Renin-Angiotensin System in the Rostral Ventrolateral Medulla of Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114191
Modern Language Association (MLA)
Ren, Chang-zhen…[et al.]. Exercise Training Improves the Altered Renin-Angiotensin System in the Rostral Ventrolateral Medulla of Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114191
American Medical Association (AMA)
Ren, Chang-zhen& Yang, Ya-Hong& Sun, Jia-cen& Wu, Zhao-Tang& Zhang, Ru-Wen& Shen, Du…[et al.]. Exercise Training Improves the Altered Renin-Angiotensin System in the Rostral Ventrolateral Medulla of Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114191