HCV-Induced Oxidative Stress: Battlefield-Winning Strategy
Joint Authors
Rebbani, Khadija
Tsukiyama-Kohara, Kyoko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
About 150 million people worldwide are chronically infected with hepatitis C virus (HCV).
The persistence of the infection is controlled by several mechanisms including the induction of oxidative stress.
HCV relies on this strategy to redirect lipid metabolism machinery and escape immune response.
The 3β-hydroxysterol Δ24-reductase (DHCR24) is one of the newly discovered host markers of oxidative stress.
This protein, as HCV-induced oxidative stress responsive protein, may play a critical role in the pathogenesis of HCV chronic infection and associated liver diseases, when aberrantly expressed.
The sustained expression of DHCR24 in response to HCV-induced oxidative stress results in suppression of nuclear p53 activity by blocking its acetylation and increasing its interaction with MDM2 in the cytoplasm leading to its degradation, which may induce hepatocarcinogenesis.
American Psychological Association (APA)
Rebbani, Khadija& Tsukiyama-Kohara, Kyoko. 2016. HCV-Induced Oxidative Stress: Battlefield-Winning Strategy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114194
Modern Language Association (MLA)
Rebbani, Khadija& Tsukiyama-Kohara, Kyoko. HCV-Induced Oxidative Stress: Battlefield-Winning Strategy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1114194
American Medical Association (AMA)
Rebbani, Khadija& Tsukiyama-Kohara, Kyoko. HCV-Induced Oxidative Stress: Battlefield-Winning Strategy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114194