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Antioxidant Activity and Cytotoxicity Effect of Cocoa Beans Subjected to Different Processing Conditions in Human Lung Carcinoma Cells
Joint Authors
Bauer, Deborah
de Abreu, Joel Pimentel
Oliveira, Hilana Salete Silva
Goes-Neto, Aristoteles
Koblitz, Maria Gabriela Bello
Teodoro, Anderson Junger
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung cancer is a common malignancy in men and the second leading cause of cancer-related mortality in men in the western world.
Phenolic cocoa ingredients have a strong antioxidative activity and the potential to have a protective effect against cancer.
In the present study, we have evaluated the influence of cocoa beans subjected to different processing conditions on cell viability and apoptosis of human lung cancer cells (A549).
We measured the viability of lung cells treated with cocoa beans, unroasted slates (US), roasted slates (RS), unroasted well fermented (UWF) cocoa, and roasted well fermented (RWF) cocoa for 24 h.
Using an MTT assay, we observed a decrease in the viability of A549 cells after treatment with cocoa bean extracts.
Flow cytometer analysis revealed that cocoa beans increased the percentage of cells in sub-G1 phase and promoted up to twofold increase of apoptotic cells when compared to the control group.
Taken together, the present study suggests that cocoa beans may have a protective effect against lung cancer.
American Psychological Association (APA)
Bauer, Deborah& de Abreu, Joel Pimentel& Oliveira, Hilana Salete Silva& Goes-Neto, Aristoteles & Koblitz, Maria Gabriela Bello& Teodoro, Anderson Junger. 2016. Antioxidant Activity and Cytotoxicity Effect of Cocoa Beans Subjected to Different Processing Conditions in Human Lung Carcinoma Cells. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114195
Modern Language Association (MLA)
Bauer, Deborah…[et al.]. Antioxidant Activity and Cytotoxicity Effect of Cocoa Beans Subjected to Different Processing Conditions in Human Lung Carcinoma Cells. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114195
American Medical Association (AMA)
Bauer, Deborah& de Abreu, Joel Pimentel& Oliveira, Hilana Salete Silva& Goes-Neto, Aristoteles & Koblitz, Maria Gabriela Bello& Teodoro, Anderson Junger. Antioxidant Activity and Cytotoxicity Effect of Cocoa Beans Subjected to Different Processing Conditions in Human Lung Carcinoma Cells. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114195