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Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury
Joint Authors
Bhatia, Jagriti
Ojha, Shreesh
Goyal, Sameer N.
Suchal, Kapil
Malik, Salma
Gamad, Nanda
Malhotra, Rajiv Kumar
Chaudhary, Uma
Arya, Dharmveer S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Kaempferol (KMP), a dietary flavonoid, has antioxidant, anti-inflammatory, and antiapoptotic effects.
Hence, we investigated the effect of KMP in ischemia-reperfusion (IR) model of myocardial injury in rats.
We studied male albino Wistar rats that were divided into sham, IR-control, KMP-20 + IR, and KMP 20 per se groups.
KMP (20 mg/kg; i.p.) was administered daily to rats for the period of 15 days, and, on the 15th day, ischemia was produced by one-stage ligation of left anterior descending coronary artery for 45 min followed by reperfusion for 60 min.
After completion of surgery, rats were sacrificed; heart was removed and processed for biochemical, morphological, and molecular studies.
KMP pretreatment significantly ameliorated IR injury by maintaining cardiac function, normalizing oxidative stress, and preserving morphological alterations.
Furthermore, there was a decrease in the level of inflammatory markers (TNF-α, IL-6, and NFκB), inhibition of active JNK and p38 proteins, and activation of ERK1/ERK2, a prosurvival kinase.
Additionally, it also attenuated apoptosis by reducing the expression of proapoptotic proteins (Bax and Caspase-3), TUNEL positive cells, and increased level of antiapoptotic proteins (Bcl-2).
In conclusion, KMP protected against IR injury by attenuating inflammation and apoptosis through the modulation of MAPK pathway.
American Psychological Association (APA)
Suchal, Kapil& Malik, Salma& Gamad, Nanda& Malhotra, Rajiv Kumar& Goyal, Sameer N.& Chaudhary, Uma…[et al.]. 2016. Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114217
Modern Language Association (MLA)
Suchal, Kapil…[et al.]. Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114217
American Medical Association (AMA)
Suchal, Kapil& Malik, Salma& Gamad, Nanda& Malhotra, Rajiv Kumar& Goyal, Sameer N.& Chaudhary, Uma…[et al.]. Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114217