Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2-ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction
Joint Authors
Liu, Chong
Xu, Huan
Fu, Shi
Chen, Yanbo
Chen, Qi
Cai, Zhikang
Zhou, Juan
Wang, Zhong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
We evaluated the effect of sulforaphane (SFN) treatment on the function and changes of expression of Nrf2-ARE pathway in the bladder of rats with bladder outlet obstruction (BOO).
Materials and Methods.
A total of 18 male Sprague-Dawley rats at age of 8 weeks were divided into 3 groups (6 of each): the sham operated group, the BOO group, and the BOO+SFN group.
We examined histological alterations and the changes of oxidative stress markers and the protein expression of the Nrf2-ARE pathway.
Results.
We found that SFN treatment could prolong micturition interval and increase bladder capacity and bladder compliance.
However, the peak voiding pressure was lower than BOO group.
SFN treatment can ameliorate the increase of collagen fibers induced by obstruction.
SFN treatment also increased the activity of SOD, GSH-Px, and CAT compared to the other groups.
The level of bladder cell apoptosis was decreased in BOO rats with SFN treatment.
Moreover, SFN could reduce the ratio of Bax/Bcl-2 expression.
Furthermore, SFN could activate the Nrf2 expression with elevation of its target antioxidant proteins.
Conclusions.
The sulforaphane-mediated decrease of oxidative stress and activation of the Nrf2-ARE pathway may ameliorate bladder dysfunction caused by bladder outlet obstruction.
American Psychological Association (APA)
Liu, Chong& Xu, Huan& Fu, Shi& Chen, Yanbo& Chen, Qi& Cai, Zhikang…[et al.]. 2016. Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2-ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114230
Modern Language Association (MLA)
Liu, Chong…[et al.]. Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2-ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114230
American Medical Association (AMA)
Liu, Chong& Xu, Huan& Fu, Shi& Chen, Yanbo& Chen, Qi& Cai, Zhikang…[et al.]. Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2-ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114230