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Antioxidant and Antihyperlipidemic Effects of Campomanesia adamantium O. Berg Root
Joint Authors
Carollo, Carlos Alexandre
Rocha, Paola dos Santos da
de Picoli Souza, Kely
dos Santos, Edson Lucas
Espindola, Priscilla Pereira de Toledo
Schmitz, Wanderlei Onofre
Pereira, Zefa Valdivina
Vieira, Maria do Carmo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Campomanesia adamantium O.
Berg, popularly known as guavira, has been used in Brazilian traditional medicine for reduction of serum lipid.
The present study was carried out to investigate the antioxidant and antihyperlipidemic effects of Campomanesia adamantium root aqueous extract (ExCA).
Phenolic compounds were quantified in the ExCA and gallic and ellagic acids were identified by HPLC.
ExCA showed efficiency in 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, with IC50 similar to butylhydroxytoluene control, and protected the erythrocytes against lipid peroxidation induced by 2,2′-azobis(2-methylpropionamidine) dihydrochloride, reducing generated malondialdehyde.
Hyperlipidemic Wistar rats treated daily by gavage during eight weeks with ExCA (200 mg/kg of body weight) showed reduced serum level of total cholesterol and triglycerides, similar to normolipidemic rats and hyperlipidemic rats treated with simvastatin (30 mg/kg of body weight) and ciprofibrate (2 mg/kg of body weight).
Moreover, the treatment with ExCA also decreased malondialdehyde serum level in the hyperlipidemic rats.
The body weight and organ mass were unmodified by ExCA in hyperlipidemic rats, except an increase of liver mass; however, the hepatic enzymes, alanine aminotransferase and aspartate aminotransferase, were unchanged.
Together, these results confirm the potential value of Campomanesia adamantium root for lowering lipid peroxidation and lipid serum level, improving risk factors for cardiometabolic diseases development.
American Psychological Association (APA)
Espindola, Priscilla Pereira de Toledo& Rocha, Paola dos Santos da& Carollo, Carlos Alexandre& Schmitz, Wanderlei Onofre& Pereira, Zefa Valdivina& Vieira, Maria do Carmo…[et al.]. 2016. Antioxidant and Antihyperlipidemic Effects of Campomanesia adamantium O. Berg Root. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114259
Modern Language Association (MLA)
Espindola, Priscilla Pereira de Toledo…[et al.]. Antioxidant and Antihyperlipidemic Effects of Campomanesia adamantium O. Berg Root. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114259
American Medical Association (AMA)
Espindola, Priscilla Pereira de Toledo& Rocha, Paola dos Santos da& Carollo, Carlos Alexandre& Schmitz, Wanderlei Onofre& Pereira, Zefa Valdivina& Vieira, Maria do Carmo…[et al.]. Antioxidant and Antihyperlipidemic Effects of Campomanesia adamantium O. Berg Root. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114259